Zebrafish Transgenic Line huORFZ Is an Effective Living Bioindicator for Detecting Environmental Toxicants
نویسندگان
چکیده
منابع مشابه
Zebrafish Transgenic Line huORFZ Is an Effective Living Bioindicator for Detecting Environmental Toxicants
Reliable animal models are invaluable for monitoring the extent of pollution in the aquatic environment. In this study, we demonstrated the potential of huORFZ, a novel transgenic zebrafish line that harbors a human upstream open reading frame of the chop gene fused with GFP reporter, as an animal model for monitoring environmental pollutants and stress-related cellular processes. When huORFZ e...
متن کاملTransgenic ZebraFish can Serve as Bioindicators of Environmental Toxicants at the Cellular Level
Nowadays, aromatic hydrocarbons, heavy metals, pesticides and endocrine disruptors are the most common environmental pollutants. Typically, chemical analysis is used to detect these toxicants. However, chemical analysis can only be applied to known toxicants using standard procedures and expensive equipment. Additionally, data obtained from chemical analysis does not faithfully reflect the phys...
متن کاملDevelopmental toxicology of cadmium in living embryos of a stable transgenic zebrafish line.
The toxic effects of cadmium and other heavy metals have been well established, and many of these and other environmental pollutants are known to be embryotoxic or teratogenic. However, it has proven difficult to identify individual cells that respond to toxicants among the wide range of cell populations in an intact animal, particularly during early development when cells are continually chang...
متن کاملEnvironmental toxicants in developing countries.
Health effects from environmental toxicants may be a more serious problem in developing countries compared with developed countries because the problem is potentiated by other factors: a) the lack of or failure to enforce regulations, which allows human exposures to genotoxic agents; b) undernourishment of the lower economic and social classes that comprise the most exposed populations from ind...
متن کاملEnvironmental Toxicants and Testicular Apoptosis
When apoptosis is improperly activated or regulated in the testis, infertility or even cancer can result. Studies have implicated elevated rates of apoptosis in infertile male patients. Pinpointing how environmental toxicity affects apoptosis is important for the advancement of preventative medicine and behavior, especially as potentially harmful compounds continue to proliferate in households ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0090160